'Passive'nanoparticles for organ-selective systemic delivery: design, mechanism and perspective

L Fu, Y Zhang, RA Farokhzad, BB Mendes… - Chemical Society …, 2023 - pubs.rsc.org
Nanotechnology has shown tremendous success in the drug delivery field for more effective
and safer therapy, and has recently enabled the clinical approval of RNA medicine, a new …

Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery

W Kim, NK Ly, Y He, Y Li, Z Yuan, Y Yeo - Advanced drug delivery reviews, 2023 - Elsevier
For systemically delivered nanoparticles to reach target tissues, they must first circulate long
enough to reach the target and extravasate there. A challenge is that the particles end up …

Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona

H Tang, Y Zhang, T Yang, C Wang, Y Zhu, L Qiu… - Nature …, 2023 - nature.com
Nanoparticles (NPs) in biological fluids form a layer of biomolecules known as the protein
corona. The protein corona has been shown to determine the biological identity and in vivo …

The role of protein corona on nanodrugs for organ-targeting and its prospects of application

S Wang, J Zhang, H Zhou, YC Lu, X Jin, L Luo… - Journal of Controlled …, 2023 - Elsevier
Nowadays, nanodrugs become a hotspot in the high-end medical field. They have the ability
to deliver drugs to reach their destination more effectively due to their unique properties and …

Delivery strategy to enhance the therapeutic efficacy of Liver Fibrosis via Nanoparticle Drug Delivery systems

J Liu, J Liu, W Mu, Q Ma, X Zhai, B Jin, Y Liu, N Zhang - ACS nano, 2024 - ACS Publications
Liver fibrosis (LF) is a pathological repair reaction caused by a chronic liver injury that affects
the health of millions of people worldwide, progressing to life-threatening cirrhosis and liver …

Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy

L Li, M Zhang, J Li, T Liu, Q Bao, X Li, J Long… - Nature …, 2023 - nature.com
Biological membranes often play important functional roles in biomimetic drug delivery
systems. We discover that the circulation time and targeting capability of biological …

Inflammation‐Responsive Cell Membrane‐Camouflaged Nanoparticles against Liver Fibrosis via Regulating Endoplasmic Reticulum Stress and Oxidative Stress

Y Bai, J Chen, S Zhang, G Xu, Z Mao, Y Ding… - Advanced …, 2024 - Wiley Online Library
Liver fibrosis represents a reversible stage of various chronic liver diseases that progresses
to cirrhosis. This condition is characterized by an imbalance between tissue damage and …

Advanced applications of DNA nanostructures dominated by DNA origami in antitumor drug delivery

Y Zhang, X Tian, Z Wang, H Wang, F Liu… - Frontiers in Molecular …, 2023 - frontiersin.org
DNA origami is a cutting-edge DNA self-assembly technique that neatly folds DNA strands
and creates specific structures based on the complementary base pairing principle. These …

DNA Nanomaterials‐Based Platforms for Cancer Immunotherapy

R Tian, Y Shang, Y Wang, Q Jiang, B Ding - Small Methods, 2023 - Wiley Online Library
The past few decades have witnessed the evolving paradigm for cancer therapy from
nonspecific cytotoxic agents to selective, mechanism‐based therapeutics, especially …

In situ characterization techniques of protein corona around nanomaterials

F Fu, D Crespy, K Landfester, S Jiang - Chemical Society Reviews, 2024 - pubs.rsc.org
Nanoparticles (NPs) inevitably interact with proteins upon exposure to biological fluids,
leading to the formation of an adsorption layer known as the “protein corona”. This corona …