An expanded lexicon for the ubiquitin code

I Dikic, BA Schulman - Nature reviews Molecular cell biology, 2023 - nature.com
Our understanding of the ubiquitin code has greatly evolved from conventional E1, E2 and
E3 enzymes that modify Lys residues on specific substrates with a single type of ubiquitin …

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

Z Fu, B Huang, J Tang, S Liu, M Liu, Y Ye, Z Liu… - Nature …, 2021 - nature.com
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

T Klemm, G Ebert, DJ Calleja, CC Allison… - The EMBO …, 2020 - embopress.org
The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …

E3 ubiquitin ligases: styles, structures and functions

Q Yang, J Zhao, D Chen, Y Wang - Molecular biomedicine, 2021 - Springer
E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination
cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2 …

Deubiquitinases in cancer

G Dewson, PJA Eichhorn, D Komander - Nature Reviews Cancer, 2023 - nature.com
Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Breaking the chains: deubiquitylating enzyme specificity begets function

MJ Clague, S Urbé, D Komander - Nature reviews Molecular cell …, 2019 - nature.com
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

Deubiquitylating enzymes and drug discovery: emerging opportunities

JA Harrigan, X Jacq, NM Martin… - Nature reviews Drug …, 2018 - nature.com
More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …

Regulating tumor suppressor genes: post-translational modifications

L Chen, S Liu, Y Tao - Signal transduction and targeted therapy, 2020 - nature.com
Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response

NA Snyder, GM Silva - Journal of Biological Chemistry, 2021 - ASBMB
Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …