Blood rheology: key parameters, impact on blood flow, role in sickle cell disease and effects of exercise

E Nader, S Skinner, M Romana, R Fort… - Frontiers in …, 2019 - frontiersin.org
Blood viscosity is an important determinant of local flow characteristics, which exhibits shear
thinning behavior: it decreases exponentially with increasing shear rates. Both hematocrit …

The red blood cell—inflammation vicious circle in sickle cell disease

E Nader, M Romana, P Connes - Frontiers in immunology, 2020 - frontiersin.org
Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …

Increased blood viscosity and red blood cell aggregation in patients with COVID‐19

E Nader, C Nougier, C Boisson… - American journal of …, 2022 - Wiley Online Library
The aim of this study was to (1) analyze blood viscosity, red blood cell (RBC) deformability,
and aggregation in hospitalized patients with Coronavirus disease 19 (COVID‐19);(2) test …

The role of blood rheology in sickle cell disease

P Connes, T Alexy, J Detterich, M Romana… - Blood reviews, 2016 - Elsevier
Studies performed in the last decades have highlighted the need to better understand the
contribution of the endothelium, vascular function, oxidative stress, inflammation …

Drying of bio-colloidal sessile droplets: Advances, applications, and perspectives

A Pal, A Gope, A Sengupta - Advances in Colloid and Interface Science, 2023 - Elsevier
Drying of biologically-relevant sessile droplets, including passive systems such as DNA,
proteins, plasma, and blood, as well as active microbial systems comprising bacterial and …

The role of RBC oxidative stress in sickle cell disease: from the molecular basis to pathologic implications

Q Wang, R Zennadi - Antioxidants, 2021 - mdpi.com
Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

E Pretorius, DB Kell - Integrative biology, 2014 - academic.oup.com
Most non-communicable diseases involve inflammatory changes in one or more vascular
systems, and there is considerable evidence that unliganded iron plays major roles in this …

Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease

E Kucukal, Y Man, A Hill, S Liu, A Bode… - American journal of …, 2020 - Wiley Online Library
Sickle cell disease (SCD) is a recessive genetic blood disorder exhibiting abnormal blood
rheology. Polymerization of sickle hemoglobin, due to a point mutation in the β‐globin gene …

White blood cell margination in microcirculation

DA Fedosov, G Gompper - Soft matter, 2014 - pubs.rsc.org
Proper functioning of white blood cells is not possible without their ability to adhere to
vascular endothelium, which may occur only if they are close enough to vessel walls. To …

iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays

ME Fay, O Oshinowo, E Iffrig, KS Fibben… - Nature …, 2023 - nature.com
While microscopy-based cellular assays, including microfluidics, have significantly
advanced over the last several decades, there has not been concurrent development of …