Cannabinoid receptors, endocannabinoids and the enzymes responsible for their
biosynthesis and degradation constitute the endocannabinoid system. In recent decades …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …

The ability of microglia to acquire diverse states of activation, or phenotypes, reflects
different features that are determinant for their contribution to homeostasis in the adult CNS …

The serine hydrolase monoacylglycerol lipase (MGLL) converts the endogenous
cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols …

Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays a crucial role catalysing the
hydrolysis of monoglycerides into glycerol and fatty acids. It links the endocannabinoid and …

The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles
in mammalian physiology. Dysfunctions in their activity have been implicated in various …

Multiple sclerosis is the most common inflammatory demyelinating disease of the central
nervous system, caused by an autoimmune response against myelin that eventually leads to …

Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …

Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …