Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

Microtubules (MTs) are an essential component of the neuronal cytoskeleton; they are
involved in various aspects of neuron development, maintenance, and functions including …

Glutamylation, introduced by tubulin tyrosine ligase-like (TTLL) enzymes, is the most
abundant modification of brain tubulin. Essential effector proteins read the tubulin …

Tubulin polyglutamylation is a predominant axonemal post-translational modification.
However, if and how axoneme polyglutamylation is essential for primary cilia and contribute …

Microtubules are dynamic cytoskeletal polymers that mediate numerous, essential functions
such as axon and dendrite growth and neuron migration throughout brain development. In …

Introduction Mutations in the RPGR gene are responsible for one of the most prevalent and
severe types of retinitis pigmentosa. Gene therapy has shown great promise to treat …

Metabolism and mechanics are intrinsically intertwined. External forces, sensed through the
cytoskeleton or distortion of the cell and organelles, induce metabolic changes in the cell …

Neurodegenerative diseases lead to a progressive demise of neuronal functions that
ultimately results in neuronal death. Besides a large variety of molecular pathways that have …

Mutations affecting the Retinitis Pigmentosa GTPase Regulator (RPGR) gene are the
commonest cause of X-linked and recessive retinitis pigmentosa (RP), accounting for 10 …

Cilia, which either generate coordinated motion or sense environmental cues and transmit
corresponding signals to the cell body, are highly conserved hair-like structures that …