Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Abstract Lipidated Rho and Rab GTP-binding proteins are transported between membranes
in complex with solubilizing factors called'guanine nucleotide dissociation inhibitors'(GDIs) …

Our understanding of the plasma membrane, once viewed simply as a static barrier, has
been revolutionized to encompass a complex, dynamic organelle that integrates the cell with …

Many cell functions rely on the coordinated activity of signalling pathways at a subcellular
scale 1, 2. However, there are few tools capable of probing and perturbing signalling …

One of the most fundamental features of biological systems is probably their ability to self-
organize in space and time on different scales. Despite many elaborate theoretical models …

Our knowledge of molecular mechanisms of receptor tyrosine kinase (RTK) signaling
advances with ever-increasing pace. Yet our understanding of how the spatiotemporal …

Decisions on the fate of cells and their functions are dictated by the spatiotemporal dynamics
of molecular signalling networks. However, techniques to examine the dynamics of these …

Bone-marrow mesenchymal stem cells (BMSC) are considered the gold standard for use in
tissue regeneration among mesenchymal stem cells (MSC). The abundance and ease of …

Activation of G-protein heterotrimers by receptors at the plasma membrane stimulates βγ-
complex dissociation from the α-subunit and translocation to internal membranes. This …