Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …

Several therapeutic monoclonal antibodies (mAbs), including those targeting epidermal
growth factor receptor, human epidermal growth factor receptor 2 (HER2), and CD20 …

Impressive advances in defining the properties of receptors for the Fc portion of
immunoglobulins (FcR) have been made over the past several years. Ligand specificities …

Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …

FcγRs have been the focus of extensive research due to their key role linking innate and
humoral immunity and their implication in both inflammatory and infectious disease. Within …

Emerging evidence has shown an imbalance in M1/M2 macrophage polarization to play an
essential role in osteoarthritis (OA) progression. However, the underlying mechanistic basis …

A key determinant for the survival of an organism is the ability to recognize and respond to
invading pathogens without damaging host tissues. This is accomplished largely by the …

Fcγ receptors (FcγR) are cell surface glycoproteins that mediate cellular effector functions of
immunoglobulin G (IgG) antibodies. Genetic variation in FcγR genes can influence …

Leukocyte Fcγ receptors (FcγR) confer potent cellular effector functions to the specificity of
IgG. FcγR‐induced leukocyte functions, including antibody‐dependent cellular cytotoxicity …

IgG antibodies are actively produced in response to antigenic challenge or passively
administered as an effective form of immunotherapy to confer immunity against foreign …