Molecular dynamics (MD) simulations have become increasingly useful in the modern drug
development process. In this review, we give a broad overview of the current application …

A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …

Recent trends in nanoparticles-based oral therapy have led to a proliferation of studies to
enhance solubility, permeability and chemical stability of many drugs. One of the significant …

Deep eutectic solvents (DES) are environmentally friendly solvents with the potential to
dissolve bioactive compounds without affecting their characteristics. DES has special …

Sažetak Low oral bioavailability as a consequence of low water solubility of drugs is a
growing challenge to the development of new pharmaceutical products. One of the most …

We developed a simple and practical method to prepare pH-responsive lignin-based
complex micelles in green solvents using purified alkali lignin. Alkali lignin (AL) was …

In recent years, the “quality by design”(QbD) approach has been used for developing
pharmaceutical formulations. This is particularly important for complex dosage forms such as …

The solubility, bioavailability and dissolution rate of drugs are important parameters for
achieving in vivo efficiency. The bioavailability of orally administered drugs depends on their …

The preferential solvation analysis was carried out by the inverse Kirkwood–Buff integrals
method on available solubility data of 7-amino-4-methylcoumarin in four aqueous co-solvent …

Computational methods play a pivotal role in the pursuit of efficient drug discovery, enabling
the rapid assessment of compound properties before costly and time-consuming laboratory …