Lung disease is the major cause of morbidity and mortality in patients with cystic fibrosis
(CF). Although CF lung disease is primarily an infectious disorder, the associated …

New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are
being developed every year, making it vital to find a non-invasive route such as nasal or …

Bacteriophages, viruses that only kill specific bacteria, are receiving substantial attention as
nontraditional antibacterial agents that may help alleviate the growing antibiotic resistance …

When killer lymphocytes recognize infected cells, perforin delivers cytotoxic proteases
(granzymes) into the target cell to trigger apoptosis. What happens to intracellular bacteria …

Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, constitutively
secretes outer membrane vesicles (OMVs) into the extracellular milieu. Although recent …

Innate immune responses play a critical role in controlling acute infections due to
Pseudomonas aeruginosa in both mice and in humans. In this review we focus on innate …

Neutrophils, or polymorphonuclear leukocytes, comprise a crucial component of innate
immunity, controlling bacterial and fungal infection through a combination of both oxidative …

Rationale: Recent evidence from clinical studies suggests that neutrophil elastase (NE)
released in neutrophilic airway inflammation is a key risk factor for the onset and …

Cystic fibrosis (CF) affects 70,000 patients worldwide. Morbidity and mortality in CF is largely
caused by lung complications due to the triad of impaired mucociliary clearance, microbial …

Cystic fibrosis is one of the most common autosomal recessive genetic diseases in
Caucasian populations. Diagnosis via newborn screening and targeted nutritional and …