This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

Epigenetics is one of the most promising and expanding fields in the current biomedical
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …

Cancer is believed to arise primarily through accumulation of genetic mutations. Although
induced pluripotent stem cell (iPSC) generation does not require changes in genomic …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

Since its discovery in 1983, the epigenetics of human cancer has been in the shadows of
human cancer genetics. But this area has become increasingly visible with a growing …

It is becoming clear that epigenetic changes are involved in human disease as well as
during normal development. A unifying theme of disease epigenetics is defects in …

Pragnancy has commonly been viewed as a cooperative interaction between a mother and
her fetus. The effects of natural selection on genes expressed in fetuses, however, may be …

The insulin-like growth factors (IGFs), IGF-I and IGF-II, comprise a conserved pair of secreted
proteins with diverse effects on growth, development, and metabolism. Insulin-like growth …

Background There is an inherited maternal predisposition to preeclampsia. Whether there is
a paternal component, however, is not known. Methods We used records of the Utah …