Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

Chronic obstructive pulmonary disease (COPD) patients frequently suffer from multiple
comorbidities, resulting in poor outcomes for these patients. Diabetes is observed at a …

In recent years, great advances have been made in the field of collection, storage, and
analysis of biological samples. Large collections of samples, biobanks, have been …

Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …

Bronchiolitis is the most common lower respiratory infection in infants, yet its pathobiology
remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized …

Background Accumulating evidence has suggested that gut microbiota dysbiosis is
commonly observed in asthmatics. However, it remains unclear whether dysbiosis is a …

Asthma is a complex disease that varies widely in prevalence across populations. The
extent to which genetic variation contributes to these disparities is unclear, as the genetics …

Background and purpose Previous studies, mostly focusing on the European population,
have reported polygenic risk scores (PRSs) might achieve risk stratification of stroke. We …

Impaired lung function in early life is associated with the subsequent development of chronic
respiratory disease. Most genetic associations with lung function have been identified in …

Background: Several studies have reported that polygenic risk scores (PRSs) can enhance
risk prediction of coronary artery disease (CAD) in European populations. However …