Intellectual disability (ID) can be caused by non-genetic and genetic factors, the latter being
responsible for more than 1700 ID-related disorders. The broad ID phenotypic and genetic …

The brain is astonishing in its complexity and capacity for change. This has fascinated
scientists for more than a century, filling the pages of this journal for the past 25 years. But a …

It is well established that the active properties of nerve and muscle cells are stabilized by
homeostatic signaling systems. In organisms ranging from Drosophila to humans, neurons …

Chemical synapses are sites of contact and information transfer between a neuron and its
partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles …

Brain development, sensory information processing, and learning and memory processes
depend on Hebbian forms of synaptic plasticity, and on the remodeling and pruning of …

Neuronal communication across synapses relies on neurotransmitter release from
presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic …

Homeostatic signaling systems are ubiquitous forms of biological regulation, having been
studied for hundreds of years in the context of diverse physiological processes including …

Neurons communicate through neurotransmitter release at specialized synaptic regions
known as active zones (AZs). Using biosensors to visualize single synaptic vesicle fusion …

Neurons communicate through Ca2+-dependent neurotransmitter release at presynaptic
active zones (AZs). Neurotransmitter release properties play a key role in defining …

The ability to adapt to changing internal and external conditions is a key feature of biological
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …