This article provides an overview of principles and barriers relevant to intracellular drug and
gene transport, accumulation and retention (collectively called as drug delivery) by means of …

Synthetic biology aims at designing new biological functions from first principles. These new
designs allow to expand the natural solution space and overcome the limitations of naturally …

Elementary mode analysis is a useful metabolic pathway analysis tool to identify the
structure of a metabolic network that links the cellular phenotype to the corresponding …

Alternative techniques and tools for analyzing biomolecular networks With the recent rapid
advances in molecular biology, high-throughput experimental methods have resulted in …

There are several methodologies based on representations of cell metabolism that share
two characteristics: the use of a metabolic network and the assumption of pseudosteady …

Elementary flux mode (EFM) analysis allows the unbiased decomposition of a metabolic
network into minimal functional units, making it a powerful tool for metabolic engineering …

Elementary flux modes (EFMs) emerged as a formal concept to describe metabolic
pathways and have become an established tool for constraint-based modeling and …

Elementary flux modes (EFMs) are non-decomposable steady-state pathways in metabolic
networks. They characterize phenotypes, quantify robustness or identify engineering targets …

Flux balance analysis (FBA) in combination with the decomposition of metabolic networks
into elementary modes has provided a route to modeling cellular metabolism. It is …

To understand the phenotypic capabilities of organisms, it is useful to characterise cellular
metabolism through the analysis of its pathways. Dynamic mathematical modelling of …