Regeneration of diseased tissue is one of the foremost concerns for millions of patients who
suffer from tissue damage each year. Local delivery of cell-laden hydrogels offers an …

Abstract 3D in vitro model systems such as spheroids and organoids provide an opportunity
to extend the physiological understanding using recapitulated tissues that mimic …

Bone defects that are congenital or the result of infection, malignancy, or trauma represent a
challenge to the global healthcare system. To address this issue, multiple research groups …

Numerous methods have been reported for the fabrication of 3D multi-cellular spheroids and
their use in stem cell culture. Current methods typically relying on the self-assembly of …

Nanomaterial-based cell sheet technology has been reported to be an effective method in
regenerative medicine and tissue engineering. Here, we summarized several types of …

Scaffold-free harvest of microtissue with a defined structure has received a great deal of
interest in cell-based assay and regenerative medicine. In this study, we developed …

Hydrogels have drawn considerable attention in the past two decades due to their excellent
biocompatibility and multi-stimuli responsiveness. They have a wide range of applications in …

In nature, many biological soft tissues with synergistic heterostructures, such as sea
cucumbers, skeletal muscles and cartilages, exhibit high functionality to adapt to complex …

Cell sheet engineering has evolved rapidly in recent years as a new approach for cell-based
therapy. Cell sheet harvest technology is important for producing viable, transplantable cell …

The aim of this study was to develop an effective cell sheet translocation method using a cell
adhesive and temperature-responsive hydroxybutyl chitosan hydrogel (HBC). The …