Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

The discoveries leading to our present understanding of the glutathione peroxidases (GPxs)
are recalled. The cytosolic GPx, now GPx1, was first described by Mills in 1957 and claimed …

Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted
lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays …

Lipid peroxidation–dependent ferroptosis has become an emerging strategy for tumor
therapy. However, current strategies not only selectively induce ferroptosis in malignant cells …

Oxygen is necessary for aerobic metabolism but can cause the harmful oxidation of lipids
and other macromolecules. Oxidation of cholesterol and phospholipids containing …

We recently described glutathione peroxidase 4 (GPX4) as a promising target for killing
therapy-resistant cancer cells via ferroptosis. The onset of therapy resistance by multiple …

As cancer cells develop resistance to apoptosis, non-apoptotic cell death modalities, such
as ferroptosis, have emerged as promising strategies to combat therapy-resistant cancers …

Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease
contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid …

Ferroptosis is a form of regulated cell death driven by oxidative injury promoting lipid
peroxidation, although detailed molecular regulators are largely unknown. Here, we show …

Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid
peroxide accumulation and redox imbalance. Ferroptosis shows specific biological and …