The landscape of mRNA nanomedicine
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …
treatment of a wide range of diseases. The recent success of the two highly efficacious …
[HTML][HTML] Drug delivery systems for RNA therapeutics
RNA-based gene therapy requires therapeutic RNA to function inside target cells without
eliciting unwanted immune responses. RNA can be ferried into cells using non-viral drug …
eliciting unwanted immune responses. RNA can be ferried into cells using non-viral drug …
[HTML][HTML] Lipid nanoparticles for mRNA delivery
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
Lipids and lipid derivatives for RNA delivery
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …
diseases through various mechanisms including knockdown of pathological genes …
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the
particular administration route and type of drug. Here we report the design of LNPs for the …
particular administration route and type of drug. Here we report the design of LNPs for the …
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
Y You, Y Tian, Z Yang, J Shi, KJ Kwak, Y Tong… - Nature biomedical …, 2023 - nature.com
The success of messenger RNA therapeutics largely depends on the availability of delivery
systems that enable the safe, effective and stable translation of genetic material into …
systems that enable the safe, effective and stable translation of genetic material into …
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs
The broad clinical application of mRNA therapeutics has been hampered by a lack of
delivery vehicles that induce protein expression in extrahepatic organs and tissues …
delivery vehicles that induce protein expression in extrahepatic organs and tissues …
Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines
After over a billion of vaccinations with messenger RNA-lipid nanoparticle (mRNA-LNP)
based SARS-CoV-2 vaccines, anaphylaxis and other manifestations of hypersensitivity can …
based SARS-CoV-2 vaccines, anaphylaxis and other manifestations of hypersensitivity can …
Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo
In humans, lipid nanoparticles (LNPs) have safely delivered therapeutic RNA to hepatocytes
after systemic administration and to antigen-presenting cells after intramuscular injection …
after systemic administration and to antigen-presenting cells after intramuscular injection …
The use of RNA-based treatments in the field of cancer immunotherapy
M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …