Drug addiction, one of the major health problems worldwide, is characterized by the loss of
control in drug intake, craving, and withdrawal. At the individual level, drugs of abuse …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

The triggering receptor expressed on myeloid 2 (TREM2) is an immune phagocytic receptor
expressed on brain microglia known to trigger phagocytosis and regulate the inflammatory …

Recent research shows that introgression between closely-related species is an important
source of adaptive alleles for a wide range of taxa. Typically, detection of adaptive …

Suicide is one of the leading causes of death globally for all ages, and as such presents a
very serious problem for clinicians worldwide. However, the underlying neurobiological …

Background Smoking and alcohol use have been associated with common genetic variants
in multiple loci. Rare variants within these loci hold promise in the identification of biological …

Nicotinic acetylcholine receptors are ligand‐gated ion channels that exogenously bind
nicotine. Nicotine produces rewarding effects by interacting with these receptors in the …

As psychiatric genetics enters an era where gene identification is finally yielding robust,
replicable genetic associations and polygenic risk scores, it is important to consider next …

Background Despite the profound clinical significance and strong heritability of alcohol use
disorder (AUD), we do not yet have a comprehensive understanding of the naturally …

Genome wide association and animal studies have implicated genetic variations in
CHRNΑ5, encoding the α5 subunit-containing nicotinic acetylcholine receptors (α5 …