Spatio-temporal regulation of the cell death machinery is essential for normal development
and homeostasis of multicellular organisms. While the molecular basis for the central cell …

During Drosophila development, neuroblasts divide to generate progeny with two different
fates. One daughter cell self-renews to maintain the neuroblast pool, whereas the other …

We constructed a large-scale functional network model in Drosophila melanogaster built
around two key transcription factors involved in the process of embryonic segmentation …

Abstract miRNAs and lncRNAs, which represent one of the most highly expressed classes of
ncRNAs in development, are attracting increasing interest. A variety of regulators is …

A variety of sheep species with diverse fecundities are kept as livestock and make up the
global agricultural economy. A mutation in the FecB gene has been implicated to be …

Tumour necrosis factor α (TNFα) is a pro-inflammatory mediator with the capacity to induce
apoptosis. An integral part of its apoptotic and inflammatory programmes is the control of cell …

Although mechanisms that lead to programmed cell death (PCD) in neurons have been
analysed extensively, little is known about how surrounding cells coordinate with it. Here we …

Background The JNK pathway is a mitogen-activated protein (MAP) kinase pathway
involved in the regulation of numerous physiological processes during development and in …

The neural stem cells of Drosophila, called neuroblasts, have the ability to self-renew and at
the same time produce many different types of neurons and glial cells. In the central brain …

Tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) is frequently
overexpressed in carcinomas, suggesting a specific role in cancer. Although TRAF4 protein …