The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

Disclosure: Dr. Maitra reports Thrive Earlier Detection has licensed an invention from Johns
Hopkins University in which Dr. Maitra is listed as an inventor. The focus of the license is on …

Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical
syndrome related to the host response to infection. The severity of infections is due to an …

Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition resulting
from direct and indirect insults to the lung. It is characterized by disruption of the endothelial …

Oxidative stress, particularly reactive oxygen species (ROS), are important for innate
immunity against pathogens. ROS directly attack pathogens, regulate and amplify immune …

Acute lung injury (ALI) is due to an uncontrolled systemic inflammatory response resulting
from direct injury to the lung or indirect injury in the setting of a systemic process. Such …

Klebsiella pneumoniae is a Gram-negative pathogen responsible for a wide range of
infections, including pneumonia and bacteremia, and is rapidly acquiring antibiotic …

Successful host defense against numerous pulmonary infections depends on bacterial
clearance by polymorphonuclear leukocytes (PMNs); however, excessive PMN …