Advances in sequencing techniques and statistical methods have made it possible not only
to predict sequences of ancestral proteins but also to identify thousands of mutations in the …

The plethora of biological functions that sustain life is rooted in the remarkable evolvability of
proteins. An emerging view highlights the importance of a protein's initial state in dictating …

Prolonged high-temperature extreme events in the ocean, marine heatwaves, can have
severe and long-lasting impacts on marine ecosystems, fisheries and associated services …

Multidimensional fitness landscapes provide insights into the molecular basis of laboratory
and natural evolution. To date, such efforts usually focus on limited protein families and a …

Understanding allostery in enzymes and tools to identify it offer promising alternative
strategies to inhibitor development. Through a combination of equilibrium and …

New enzyme functions often evolve through the recruitment and optimization of latent
promiscuous activities. How do mutations alter the molecular architecture of enzymes to …

Protein evolution depends on the adaptation of these molecules to different functional
challenges. This occurs by tuning their biochemical, biophysical, and structural traits through …

New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1, 2, 4-triazole-5-yl) thio) methyl)-4H-1, 2, 4-
triazole-3-thiol derivatives have been designed, synthesized and studied their antimicrobial …

The evolutionary role of conformational exchange in the emergence and preservation of
function within structural homologs remains elusive. While protein engineering has revealed …

Understanding the underlying mechanisms behind protein allostery and non-additivity of
substitution outcomes (ie, epistasis) is critical when attempting to predict the functional …