Functionalizing DNA origami to investigate and interact with biological systems

GA Knappe, EC Wamhoff, M Bathe - Nature Reviews Materials, 2023 - nature.com
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

Recent developments in reversible photoregulation of oligonucleotide structure and function

AS Lubbe, W Szymanski, BL Feringa - Chemical Society Reviews, 2017 - pubs.rsc.org
There is a growing interest in the photoregulation of biological functions, due to the high
level of spatiotemporal precision achievable with light. Additionally, light is non-invasive and …

Chemistry can make strict and fuzzy controls for bio-systems: DNA nanoarchitectonics and cell-macromolecular nanoarchitectonics

M Komiyama, K Yoshimoto, M Sisido… - Bulletin of the Chemical …, 2017 - academic.oup.com
In this review, we introduce two kinds of bio-related nanoarchitectonics, DNA
nanoarchitectonics and cell-macromolecular nanoarchitectonics, both of which are basically …

Reconfigurable DNA origami nanocapsule for pH-controlled encapsulation and display of cargo

H Ijäs, I Hakaste, B Shen, MA Kostiainen, V Linko - ACS nano, 2019 - ACS Publications
DNA nanotechnology provides a toolbox for creating custom and precise nanostructures
with nanometer-level accuracy. These nano-objects are often static by nature and serve as …

Nucleic acid-based drug delivery strategies

X Tan, F Jia, P Wang, K Zhang - Journal of Controlled Release, 2020 - Elsevier
Nucleic acids have not been widely considered as an optimal material for drug delivery.
Indeed, unmodified nucleic acids are enzymatically unstable, too hydrophilic for cell uptake …

DNA‐based nanoarchitectures as eminent vehicles for smart drug delivery systems

M Komiyama, N Shigi, K Ariga - Advanced Functional Materials, 2022 - Wiley Online Library
In order to cure diseases efficiently with minimal side effects in sophisticated medicine,
eminent drugs must be selectively delivered to diseased parts and allow to work only there …

Stimuli‐Responsive DNA‐Functionalized Nano‐/Microcontainers for Switchable and Controlled Release

CH Lu, I Willner - Angewandte Chemie International Edition, 2015 - Wiley Online Library
Stimuli‐responsive DNA‐functionalized nano‐and microcontainers composed of
mesoporous SiO2 nanoparticles (MP SiO2 NPs), microcapsules, or micelles/vesicles act as …

DNA‐Tetrahedra Corona‐Modified Hydrogel Microcapsules:“Smart” ATP‐or microRNA‐Responsive Drug Carriers

A Fischer, P Zhang, Y Ouyang, YS Sohn, O Karmi… - Small, 2022 - Wiley Online Library
The assembly of adenosine triphosphate (ATP)‐responsive and miRNA‐responsive DNA
tetrahedra‐functionalized carboxymethyl cellulose hydrogel microcapsules is presented …

Aptamer-functionalized micro-and nanocarriers for controlled release

M Vazquez-Gonzalez, I Willner - ACS Applied Materials & …, 2021 - ACS Publications
Sequence-specific nucleic acids recognizing low-molecular-weight ligands or
macromolecules (aptamers) have found growing interest for biomedical applications. The …

DNA origami nanomachines

M Endo, H Sugiyama - Molecules, 2018 - mdpi.com
DNA can assemble various molecules and nanomaterials in a programmed fashion and is a
powerful tool in the nanotechnology and biology research fields. DNA also allows the …