Increased VWF and decreased ADAMTS-13 in COVID-19: creating a milieu for (micro) thrombosis

EJ Favaloro, BM Henry, G Lippi - Seminars in thrombosis and …, 2021 - thieme-connect.com
von Willebrand factor (VWF) is a large adhesive multimeric protein involved in hemostasis.
The larger the size (or number of VWF multimers), the greater the functionality of the protein …

Evolution of hemostasis testing: a personal reflection covering over 40 years of history

EJ Favaloro - Seminars in Thrombosis and Hemostasis, 2024 - thieme-connect.com
There is no certainty in change, other than change is certain. As Seminars in Thrombosis
and Hemostasis celebrates 50 years of publication, I felt it appropriate to reflect on my own …

The role of the von Willebrand factor collagen-binding assay (VWF: CB) in the diagnosis and treatment of von Willebrand disease (VWD) and way beyond: a …

EJ Favaloro - Seminars in Thrombosis and Hemostasis, 2024 - thieme-connect.com
The von Willebrand factor (VWF) collagen binding (VWF: CB) assay was first reported for
use in von Willebrand diagnostics in 1986, by Brown and Bosak. Since then, the VWF: CB …

Comparative assessment of von Willebrand factor multimers vs activity for von Willebrand disease using modern contemporary methodologies

EJ Favaloro, S Oliver, S Mohammed, R Vong - Haemophilia, 2020 - Wiley Online Library
Abstract Introduction Diagnosis of von Willebrand disease (VWD) is challenging due to
heterogeneity of VWD and test limitations. Many von Willebrand factor (VWF) assays are …

Navigating the myriad of von Willebrand factor assays

EJ Favaloro - Hämostaseologie, 2020 - thieme-connect.com
von Willebrand factor (VWF) represents a large and complex adhesive plasma protein
whose main function is to provide a bridge between blood platelets and damaged …

How we diagnose 2M von Willebrand disease (VWD): use of a strategic algorithmic approach to distinguish 2M VWD from other VWD types

EJ Favaloro, S Mohammed, R Vong, S Oliver… - …, 2021 - Wiley Online Library
Introduction von Willebrand disease (VWD) is the most common inherited bleeding disorder
and caused by an absence, deficiency or defect in von Willebrand factor (VWF). VWD is …

Gastrointestinal Angiodysplasia Resolution After Transcatheter Aortic Valve Implantation

LCMJ Goltstein, MJP Rooijakkers… - JAMA Network …, 2024 - jamanetwork.com
Importance Heyde syndrome is the cooccurrence of aortic stenosis and gastrointestinal
bleeding secondary to vascular lesions, including angiodysplasias. Several studies have …

von Willebrand factor multimer analysis and classification: a comprehensive review and updates

A Saadalla, J Seheult, RK Pruthi… - Seminars in Thrombosis …, 2023 - thieme-connect.com
Von Willebrand factor (VWF) is a multimeric glycoprotein with essential roles in primary
hemostasis. Patients with von Willebrand disease (VWD), due to quantitative and/or …

Multimer Analysis of Von Willebrand Factor in Von Willebrand Disease with a Hydrasys Semi-Automatic Analyzer—Single-Center Experience

I Skornova, T Simurda, J Stasko, J Zolkova, J Sokol… - Diagnostics, 2021 - mdpi.com
von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder.
This disorder develops as a result of defects and/or deficiency of the plasma protein von …

Utility of the platelet function analyser (PFA-100/200) for exclusion or detection of von Willebrand disease: A study 22 years in the making

EJ Favaloro - Thrombosis research, 2020 - Elsevier
Introduction von Willebrand disease (VWD) is the most common inherited bleeding disorder
and may alternatively arise as an acquired condition (AVWS). These represent deficiency …