Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …
reactions in the solid state. A broad chemical definition of crystal engineering was published …
Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …
but the solubility parameter cannot compromise, and so different approaches are employed …
Molecular photoswitches in aqueous environments
Molecular photoswitches enable dynamic control of processes with high spatiotemporal
precision, using light as external stimulus, and hence are ideal tools for different research …
precision, using light as external stimulus, and hence are ideal tools for different research …
Advances in oral drug delivery
The oral route is the most common route for drug administration. It is the most preferred
route, due to its advantages, such as non-invasiveness, patient compliance and …
route, due to its advantages, such as non-invasiveness, patient compliance and …
[HTML][HTML] Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability
P Khadka, J Ro, H Kim, I Kim, JT Kim, H Kim… - Asian journal of …, 2014 - Elsevier
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug
compounds that limits in vivo bioavailability owing to their low dissolution rate in the …
compounds that limits in vivo bioavailability owing to their low dissolution rate in the …
Drug delivery approaches in addressing clinical pharmacology-related issues: opportunities and challenges
H Wen, H Jung, X Li - The AAPS journal, 2015 - Springer
Various drug delivery approaches can be used to maximize therapeutic efficacy and
minimize side effects, by impacting absorption, distribution, metabolism, and elimination …
minimize side effects, by impacting absorption, distribution, metabolism, and elimination …
Polymorph impact on the bioavailability and stability of poorly soluble drugs
R Censi, P Di Martino - Molecules, 2015 - mdpi.com
Drugs with low water solubility are predisposed to poor and variable oral bioavailability and,
therefore, to variability in clinical response, that might be overcome through an appropriate …
therefore, to variability in clinical response, that might be overcome through an appropriate …
Drug solubility: importance and enhancement techniques
KT Savjani, AK Gajjar, JK Savjani - … Scholarly Research Notices, 2012 - Wiley Online Library
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system,
is one of the important parameters to achieve desired concentration of drug in systemic …
is one of the important parameters to achieve desired concentration of drug in systemic …
Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …