Role of proteases in chronic obstructive pulmonary disease

KC Pandey, S De, PK Mishra - Frontiers in pharmacology, 2017 - frontiersin.org
Chronic obstructive pulmonary disease (COPD) is generally associated with progressive
destruction of airways and lung parenchyma. Various factors play an important role in the …

The roles of dipeptidyl peptidase 4 (DPP4) and DPP4 inhibitors in different lung diseases: new evidence

T Zhang, X Tong, S Zhang, D Wang, L Wang… - Frontiers in …, 2021 - frontiersin.org
CD26/Dipeptidyl peptidase 4 (DPP4) is a type II transmembrane glycoprotein that is widely
expressed in various organs and cells. It can also exist in body fluids in a soluble form …

DPP4, the Middle East respiratory syndrome coronavirus receptor, is upregulated in lungs of smokers and chronic obstructive pulmonary disease patients

LJM Seys, W Widagdo, FM Verhamme… - Clinical Infectious …, 2018 - academic.oup.com
Abstract Background Middle East respiratory syndrome coronavirus (MERS-CoV) causes
pneumonia with a relatively high case fatality rate in humans. Smokers and chronic …

Proteases and their inhibitors in chronic obstructive pulmonary disease

T Dey, J Kalita, S Weldon, CC Taggart - Journal of clinical medicine, 2018 - mdpi.com
In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the
leading cause of mortality worldwide. Despite much development in the area of drug …

Boning up on DPP4, DPP4 substrates, and DPP4-adipokine interactions: Logical reasoning and known facts about bone related effects of DPP4 inhibitors

L Glorie, PC d'Haese, A Verhulst - Bone, 2016 - Elsevier
Abstract Dipeptidyl peptidase 4 (DPP4) is a conserved exopeptidase with an important
function in protein regulation. The activity of DPP4, an enzyme which can either be anchored …

The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo

SR Lin, CH Chang, MJ Tsai, H Cheng… - … in Chronic Disease, 2019 - journals.sagepub.com
Dipeptidyl peptidase IV (DPP-4), an incretin glucagon-like peptide-1 (GLP-1) degrading
enzyme, contains two forms and it can exert various physiological functions particular in …

Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD

D Mahor, V Kumari, K Vashisht, R Galgalekar… - BMC pulmonary …, 2020 - Springer
Background The increasing trend of Chronic Obstructive Pulmonary Disease (COPD) in
becoming the third leading cause of deaths by 2020 is of great concern, globally as well as …

Paraoxonase 1 activity in patients with chronic obstructive pulmonary disease

L Rumora, MG Rajković, LM Kopčinović… - COPD: Journal of …, 2014 - Taylor & Francis
Abstract Introduction: Paraoxonase 1 (PON1) is an antioxidative enzyme manly associated
with high density lipoproteins (HDL) in the peripheral blood. The aim of this study was to …

Serum activity of DPPIV and its expression on lymphocytes in patients with melanoma and in people with vitiligo

IZ Matić, M Đorđić, N Grozdanić, A Damjanović… - BMC immunology, 2012 - Springer
Background Dipeptidyl peptidase IV, a multifunctional serine protease, is implicated in
regulation of malignant transformation, promotion and further progression of cancer, exerting …

Expression and clinical significance of serum dipeptidyl peptidase IV chronic obstructive pulmonary disease

XY Chang, Y Yang, XQ Jia, Y Wang, LN Peng… - The American Journal of …, 2016 - Elsevier
Objective The purpose of this study is to explore the correlation between serum dipeptidyl
peptidase IV (DPPIV) and chronic obstructive pulmonary disease (COPD) at its various …