The cytoplasmic protein-tyrosine kinase BTK plays an essential role for differentiation and
survival of B-lineage cells and, hence, represents a suitable drug target. The number of BTK …

Clinical development of BTK kinase inhibitors for treating autoimmune diseases has lagged
behind development of these drugs for treating cancers, due in part from concerns over the …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase
important in B‐lymphocyte development, differentiation, and signaling. Btk is a member of …

Mice lacking the p110δ catalytic subunit of phosphatidylinositol 3-kinase have reduced
numbers of B1 and marginal zone B cells, reduced levels of serum immunoglobulins …

Control of integrin-mediated adhesion and migration by chemokines plays a critical role in B
cell development, differentiation, and function; however, the underlying signaling …

▪ Abstract The Tec family tyrosine kinases are now recognized as important mediators of
antigen receptor signaling in lymphocytes. Three members of this family, Itk, Rlk, and Tec …

Cytoplasmic protein‐tyrosine kinases (PTKs) are enzymes involved in transducing a vast
number of signals in metazoans. The importance of the Tec family of kinases was …

The Btk family kinases represent new members of non-receptor tyrosine kinases, which
include Btk/Atk, Itk/Emt/Tsk, Bmx/Etk, and Tec. They are characterized by having four …

Blood clotting is a finely regulated process that is essential for hemostasis. However, when
dysregulated or spontaneous, it promotes thrombotic disorders. The fact that these are …