Computational methods in glaucoma research: current status and future outlook
MJ Kim, CA Martin, J Kim, MM Jablonski - Molecular Aspects of Medicine, 2023 - Elsevier
Advancements in computational techniques have transformed glaucoma research, providing
a deeper understanding of genetics, disease mechanisms, and potential therapeutic targets …
a deeper understanding of genetics, disease mechanisms, and potential therapeutic targets …
Novel benzene sulfonamides with acetylcholinesterase and carbonic anhydrase inhibitory actions
A series of benzene sulfonamides 15–26 were synthesized and determined for their in vitro
and in silico inhibitory profiles toward acetylcholinesterase (AChE) and carbonic anhydrases …
and in silico inhibitory profiles toward acetylcholinesterase (AChE) and carbonic anhydrases …
Synthesis, In Vivo Anticonvulsant Activity Evaluation and In Silico Studies of Some Quinazolin-4 (3H)-One Derivatives
Two series,“a” and “b”, each consisting of nine chemical compounds, with 2, 3-disubstituted
quinazolin-4 (3H)-one scaffold, were synthesized and evaluated for their anticonvulsant …
quinazolin-4 (3H)-one scaffold, were synthesized and evaluated for their anticonvulsant …
Prospects for Prostate Cancer Chemotherapy: Cytotoxic Evaluation and Mechanistic Insights of Quinolinequinones with ADME/PK Profile
AT Jannuzzi, AM Yilmaz Goler, A Biswas, S Mondal… - Biomedicines, 2024 - mdpi.com
The evaluation of in vitro biological activity of several previously reported quinolinequinones
(AQQ1–5) against 60 human cancer cell lines (NCI-60) used by the National Cancer …
(AQQ1–5) against 60 human cancer cell lines (NCI-60) used by the National Cancer …
In silico evaluation of a new compound incorporating 4 (3H)-quinazolinone and sulfonamide as a potential inhibitor of a human carbonic anhydrase
The present study investigates the potential of a new compound containing sulfonamide and
4 (3H)-quinazolinone to inhibit the hCA-IIX enzyme using in silico methods. Density …
4 (3H)-quinazolinone to inhibit the hCA-IIX enzyme using in silico methods. Density …
Synthesis, Antibacterial, and Antimonooxidase Activity of 4-(2-Methyl-1, 3-oxazol-5-yl) benzenesulfonamide
OA Gasilina, AA Romanycheva, AA Shetnev… - Russian Journal of …, 2023 - Springer
A new method for obtaining 4-(2-methyl-1, 3-oxazol-5-yl) benzenesulfonamide, an
antiglaucomatous drug candidate oxazopt, was developed using a diazotization reaction. A …
antiglaucomatous drug candidate oxazopt, was developed using a diazotization reaction. A …