Cisplatin is one of the most widely used chemotherapeutic agents for various solid tumors in
the clinic due to its high efficacy and broad spectrum. The antineoplastic activity of cisplatin …

Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Improved model systems to predict drug efficacy, interactions, and drug-induced kidney
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …

Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

This article reviews the current knowledge on the mechanisms of adaptive response to low
doses of ionizing radiation or chemical exposure. A better knowledge of these mechanisms …

Since March 2013, animal use for cosmetics testing for the European market has been
banned. This requires a renewed view on risk assessment in this field. However, in other …

The toxicogenomics field aims to understand and predict toxicity by using 'omics' data in
order to study systems-level responses to compound treatments. In recent years there has …

High content omic techniques in combination with stable human in vitro cell culture systems
have the potential to improve on current pre-clinical safety regimes by providing detailed …

Reactive oxygen species (ROS), which are a byproduct of oxidative metabolism, serve as
signaling molecules in a number of physiological settings. However, if their levels are not …

Cisplatin is one of the most widely used chemotherapeutic agents for the treatment of solid
tumours. The major dose-limiting factor is nephrotoxicity, in particular in the proximal tubule …