Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Sex steroids are major promoters of the growth of breast and prostate cancers. This Review
by Poutanen et al. describes the development of treatments for these cancer types that act to …

Context Systemic therapies, combined with local treatment for high-risk prostate cancer, are
recommended by the international guidelines for specific subgroups of patients; however, for …

Introduction: Androgen deprivation therapy (ADT) is the mainstay for advanced, hormone-
sensitive prostate cancer, and options include surgical castration, luteinizing hormone …

Prostate cancer is uniquely dependent on androgens. Despite years of research on the
relationship between androgens and prostate cancer, many questions remain as to the …

The first case of prostate cancer was identified by histological examination by J. Adams, a
surgeon at The London Hospital, in 1853. In his report, Adams noted that the condition was …

Testosterone is an essential steroid hormone associated with a wide variety of biological
processes in humans. In prostate cancer, androgen signaling is an important driver of tumor …

Abstract Introduction Prostate cancer (PCa) has been recognized as an androgen-sensitive
disease since the investigations from Huggins and Hodges in 1941. Thanks to these …

The mechanism by which gastrin promotes pancreatic cancer cell metastasis is unclear. The
process of directing polarized cancer cells toward the extracellular matrix is principally …

Breast cancer (BC) and prostate cancer (PC) are the second most common malignant
tumors in women and men in western countries, respectively. The risks of death are 14% for …