Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for
Pathogenesis* | Endocrine Reviews | Oxford Academic Skip to Main Content Advertisement …

Obesity, particularly the abdominal phenotype, is associated with several reproductive
disturbances. Whereas mechanisms by which obesity affect fertility are complex and still not …

Sex hormone binding globulin (SHBG) is a glycoprotein composed of two 373‐amino‐acid
subunits. The SHBG gene and a promotor region have been identified. The SHBG receptor …

GH plays a pivotal role in regulating body growth and development, which is modulated by
sex steroids. A close interplay between estrogen and GH leads to attainment of …

Smokers are insulin resistant, exhibit several aspects of the insulin resistance syndrome,
and are at an increased risk for type 2 diabetes. Prospectively, the increased risk for …

Estrogen and progestins have been used by millions of women as effective combined oral
contraceptives. Oral contraceptives (OCs) modify surrogate markers such as lipoproteins …

ContextAlthough oligomenorrhea has been associated cross-sectionally with insulin
resistance and glucose intolerance, it is not known whether oligomenorrhea is a marker for …

Hyperinsulinemia is a common finding in hyperandrogenic women, during pregnancy, and
in women using oral contraceptives. To test whether sex hormone treatment can induce …

Summary objective Sex differences are found in most components of the insulin resistance
syndrome and the associated cardiovascular risk profile. These differences are attributed to …

Objective To distinguish the effects of menopause, gender and age on serum lipid risk
markers for vascular disease, including high-density lipoprotein cholesterol (HDL-C) …