Ovarian cancer has poor survival rates due to a combination of diagnosis at advanced
disease stages and disease recurrence as a result of platinum chemotherapy resistance …

Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

Significance: Epigenetic inactivation of pivotal genes involved in cell growth is a hallmark of
human pathologies, in particular cancer. Histone acetylation balance obtained through …

Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the
concept of malignant pathologies as being solely genetic-based conditions. The epigenetic …

Dysregulation of gene expression is a frequent occurrence in oral squamous cell carcinoma
(OSCC). However, accumulating evidence suggests that in contrast to genetics, epigenetic …

Squamous cell carcinoma of the oral region (OSCC) is one of the most common and highly
aggressive malignancies worldwide, despite the fact that significant results have been …

Epigenetic modulation, including acetylation, methylation, phosphorylation, and
ubiquitination, plays a pivotal role in regulation of gene expression. Histone acetylation—a …

Histone deacetylase (HDAC) inhibitors are an exciting new addition to the arsenal of cancer
therapeutics. The inhibition of HDAC enzymes by HDAC inhibitors shifts the balance …

Introduction: A key feature of malignant cells is inappropriate gene suppression resulting in
uncontrolled proliferation, continued cell cycling and a lack of differentiation. Histone …

One of the most promising strategies to increase the efficacy of standard chemotherapy
drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis) …