The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets
SL Wood, M Pernemalm, PA Crosbie… - Cancer treatment …, 2014 - Elsevier
Non-small cell lung cancer (NSCLC) accounts for> 80% of lung cancer cases and currently
has an overall five-year survival rate of only 15%. Patients presenting with advanced stage …
has an overall five-year survival rate of only 15%. Patients presenting with advanced stage …
Matrix metalloproteinases as novel biomarker s and potential therapeutic targets in human cancer
The matrix metalloproteinase (MMP) family of enzymes is comprised of critically important
extracellular matrix remodeling proteases whose activity has been implicated in a number of …
extracellular matrix remodeling proteases whose activity has been implicated in a number of …
Matrix metalloproteinases: their functional role in lung cancer
Lung malignancy is the foremost cause of cancer-related deaths globally and is frequently
related to long-term tobacco smoking. Recent studies reveal that the expression of matrix …
related to long-term tobacco smoking. Recent studies reveal that the expression of matrix …
[HTML][HTML] A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
MT Landi, N Chatterjee, K Yu, LR Goldin… - The american journal of …, 2009 - cell.com
Three genetic loci for lung cancer risk have been identified by genome-wide association
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not …
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not …
Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium
To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia,
and tuberculosis) in the development of lung cancer, the authors conducted a pooled …
and tuberculosis) in the development of lung cancer, the authors conducted a pooled …
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
MN Timofeeva, RJ Hung, T Rafnar… - Human molecular …, 2012 - academic.oup.com
Recent genome-wide association studies (GWASs) have identified common genetic variants
at 5p15. 33, 6p21–6p22 and 15q25. 1 associated with lung cancer risk. Several other …
at 5p15. 33, 6p21–6p22 and 15q25. 1 associated with lung cancer risk. Several other …
Key molecular mechanisms in lung cancer invasion and metastasis: a comprehensive review
F Perlikos, KJ Harrington, KN Syrigos - Critical reviews in oncology …, 2013 - Elsevier
Lung cancer remains one of the most common and malignant cancers worldwide. It is most
often diagnosed at late stages, when it has already presented local invasion and distal …
often diagnosed at late stages, when it has already presented local invasion and distal …
S100A4 calcium-binding protein is key player in tumor progression and metastasis: preclinical and clinical evidence
The fatality of cancer is mainly bestowed to the property of otherwise benign tumor cells to
become malignant and invade surrounding tissues by circumventing normal tissue barriers …
become malignant and invade surrounding tissues by circumventing normal tissue barriers …
The genetic and epigenetic footprint in idiopathic pulmonary fibrosis and familial pulmonary fibrosis: a state-of-the-art review
Idiopathic pulmonary fibrosis (IPF) is a rare disease of the lung with a largely unknown
etiology and a poor prognosis. Intriguingly, forms of familial pulmonary fibrosis (FPF) have …
etiology and a poor prognosis. Intriguingly, forms of familial pulmonary fibrosis (FPF) have …
Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium
Background Genome-wide association studies have identified three chromosomal regions
at 15q25, 5p15, and 6p21 as being associated with the risk of lung cancer. To confirm these …
at 15q25, 5p15, and 6p21 as being associated with the risk of lung cancer. To confirm these …