Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

Studies of the identity and physiological function of mesenchymal stromal cells (MSCs) have
been hampered by a lack of markers that permit both prospective identification and fate …

T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-
renewal and lineage specification. Beyond a role in energetic support, new evidence …

Recent advances in metabolomics and computational analysis have deepened our
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to …

Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor
markers are useful for isolating a subset of liver cells with stem cell features, known as …

As sites of cellular respiration and energy production, mitochondria play a central role in cell
metabolism. Cell differentiation is associated with an increase in mitochondrial content and …

The identification of activating NOTCH1 mutations in T cell acute lymphoblastic leukemia (T-
ALL) led to clinical testing of γ-secretase inhibitors (GSIs) that prevent NOTCH1 activation …