[HTML][HTML] Histone deacetylases modulate resistance to the therapy in lung cancer

E Contreras-Sanzón, H Prado-Garcia… - Frontiers in …, 2022 - frontiersin.org
The acetylation status of histones located in both oncogenes and tumor suppressor genes
modulate cancer hallmarks. In lung cancer, changes in the acetylation status are associated …

[HTML][HTML] Control of cell growth and proliferation by the tribbles pseudokinase: Lessons from Drosophila

LL Dobens, C Nauman, Z Fischer, X Yao - Cancers, 2021 - mdpi.com
Simple Summary Tribbles pseudokinases represent a sub-branch of the CAMK
(Ca2+/calmodulin-dependent protein kinase) subfamily and are associated with disease …

Molecular characterization of TRIB1 gene and its role in regulation of steroidogenesis in Bos grunniens granulosa cells

D Zhao, Y Fan, X Xiong, S Yin, W Fu, Y Ma, Y Yue… - Theriogenology, 2022 - Elsevier
To explore the expression pattern of the TRIB1 gene in yak follicles and its effect on the
steroidogenesis of granulosa cells (GCs). Here, 4–5 years old female yaks were treated as …

Aging deteriorated liver Ischemia and reperfusion injury by suppressing Tribble's proteins 1 mediated macrophage polarization

Q Chen, Y Song, N Yang, X Ai, L Pu, L Kong - Bioengineered, 2022 - Taylor & Francis
Aggravated liver injury has been reported in aged ischemia/reperfusion-stressed livers;
however, the mechanism of aged macrophage inflammatory regulation is not well …

[HTML][HTML] New insights into the suppression of inflammation and lipid accumulation by JAZF1

W Chen, Y Zhong, Y Yuan, M Zhu, W Hu, N Liu, D Xing - Genes & Diseases, 2023 - Elsevier
Atherosclerosis is one of the leading causes of disease and death worldwide. The
identification of new therapeutic targets and agents is critical. JAZF1 is expressed in many …

Polymorphisms of TRIB1 genes for coronary artery disease and stroke risk: A systematic review and meta-analysis

J Jiang, X Chen, C Li, X Du, H Zhou - Gene, 2023 - Elsevier
Background and aims In recent years, the results of the association between Tribbles
Pseudokinase 1 (TRIB1) gene polymorphism and the risk of coronary artery disease (CAD) …

The biogenesis and transport of triglyceride-rich lipoproteins

L Zhang, X Wang, XW Chen - Trends in Endocrinology & Metabolism, 2024 - cell.com
Triglyceride-rich lipoproteins (TRLs) play essential roles in human health and disease by
transporting bulk lipids into the circulation. This review summarizes the fundamental …

Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar

D Al‐Sharshani, D Velayutham… - … Genetics & Genomic …, 2023 - Wiley Online Library
Background Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases
(CVDs), type 2 diabetes mellitus (T2DM), and non‐alcoholic fatty liver disease (NAFLD) …

[HTML][HTML] Adipocyte-specific tribbles pseudokinase 1 regulates plasma adiponectin and plasma lipids in mice

EE Ha, GI Quartuccia, R Ling, C Xue, RA Karikari… - Molecular …, 2022 - Elsevier
Objective Multiple genome-wide association studies (GWAS) have identified SNPs in the
8q24 locus near TRIB1 that are significantly associated with plasma lipids and other markers …

Genome-wide association study of liver fat, iron, and extracellular fluid fraction in the UK Biobank

C O'Dushlaine, M Germino, N Verweij, JB Nielsen… - medRxiv, 2021 - medrxiv.org
Abdominal magnetic resonance imaging (MRI) represents a non-invasive approach
allowing the extraction of clinically informative phenotypes. We developed an automated …