The endoplasmic reticulum (ER) is a principal subcellular organelle responsible for protein
quality control in the secretory pathway, preventing protein misfolding and aggregation …

The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and
degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is …

Nanoplastics (NPs) pollution poses a huge threat to the ecosystem and has become one of
the environmental pollutants that have attracted much attention. There is increasing …

To what extent and how post-transcriptional dysregulation affects aging proteome remains
unclear. Here, we provide proteomic data of whole-tissue lysates (WTL) and low-solubility …

Ethnopharmacological relevance Weifuchun capsule (WFC) is a traditional Chinese patent
medicine for chronic atrophic gastritis (CAG) in clinic. However, the mechanism of action of …

Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that
seriously affects the quality of life of patients due to its disabling and pain-causing …

Age-related decline in skeletal muscle regenerative capacity is multifactorial, yet the
contribution of immune dysfunction to regenerative failure is unknown. Macrophages are …

Skeletal muscle regeneration involves a signaling network that regulates the proliferation,
differentiation, and fusion of muscle precursor cells to injured myofibers. IRE1α, one of the …

Skeletal muscle regeneration involves coordinated activation of an array of signaling
pathways. Fibroblast growth factor–inducible 14 (Fn14) is a bona fide receptor for the …

The unfolded protein response (UPR) is a sensing and signaling pathway that surveys the
endoplasmic reticulum (ER) for protein folding challenges and responds whenever issues …