For some membrane proteins, detergent-mediated solubilization compromises protein
stability and functionality, often impairing biophysical and structural analyses. Hence …

Twenty years ago, a number of eminent pharmaceutical scientists collaborated on an article
describing a rational approach to developing stable lyophilized protein formulations …

The aim of structural biology has been always the study of biological macromolecules
structures and their mechanistic behaviour at molecular level. To achieve its goal, multiple …

Proteins are functional macromolecules in living organisms including mammals and thus
human beings. They are involved in almost all biological processes, either as the main …

VMXi is a new high-flux microfocus macromolecular crystallography beamline at Diamond
Light Source. The beamline, dedicated to fully automated and fully remote data collection of …

Protein crystallography has significantly advanced in recent years, with in situ data
collection, in which crystals are placed in the X-ray beam within their growth medium, being …

A fixed-target approach to high-throughput room-temperature serial synchrotron
crystallography with oscillation is described. Patterned silicon chips with microwells provide …

Capturing protein structural dynamics in real-time has tremendous potential in elucidating
biological functions and providing information for structure-based drug design. While time …

De novo membrane protein structure determination is often limited by the availability of large
crystals and the difficulties in obtaining accurate diffraction data for experimental phasing …

A sample delivery system is one of the key parts of serial crystallography. It is the main
limiting factor affecting the application of serial crystallography. At present, although a variety …