Decoding stem cells: an overview on planarian stem cell heterogeneity and lineage progression

MD Molina, F Cebrià - Biomolecules, 2021 - mdpi.com
Planarians are flatworms capable of whole-body regeneration, able to regrow any missing
body part after injury or amputation. The extraordinary regenerative capacity of planarians is …

[HTML][HTML] The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration

JJ Chen, K Lei - Zoological Research, 2023 - ncbi.nlm.nih.gov
Planarians represent the most primitive bilateral triploblastic animals. Most planarian
species exhibit mechanisms for whole-body regeneration, exemplified by the regeneration …

The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

I Ensinck, A Maman, WS Albihlal, M Lassandro… - Elife, 2023 - elifesciences.org
Abstract N6-methyladenosine (m6A), the most abundant mRNA modification, is deposited in
mammals/insects/plants by m6A methyltransferase complexes (MTC) comprising a catalytic …

Fibrillarin homologs regulate translation in divergent cell lineages during planarian homeostasis and regeneration

J Chen, Y Li, Y Wang, H Wang, J Yang, X Pan… - The EMBO …, 2024 - embopress.org
Tissue homeostasis and regeneration involve complex cellular changes. The role of rRNA
modification-dependent translational regulation in these processes remains largely …

m6A promotes planarian regeneration

G Cui, JY Zhou, XY Ge, BF Sun, GG Song… - Cell …, 2023 - Wiley Online Library
Regeneration is the regrowth of damaged tissues or organs, a vital process in response to
damages from primitive organisms to higher mammals. Planarian possesses active whole …

The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates

M Wiggans, SJ Zhu, AM Molinaro, BJ Pearson - BMC biology, 2023 - Springer
Abstract Background The flatworm planarian, Schmidtea mediterranea, has a large
population of adult stem cells (ASCs) that replace any cell type during tissue turnover or …

Profling of m6A methylation in porcine intramuscular adipocytes and unravelling PHKG1 repress porcine intramuscular lipid deposition in an m6A-dependent manner

M Chao, M Wang, H Han, Y Liu, X Sun, T Tian… - International Journal of …, 2024 - Elsevier
Intramuscular fat (IMF) content is mainly determined by intramuscular preadipocyte
adipogenesis. Epigenetic modifications are known to have a regulatory effect on IMF. As N6 …

[HTML][HTML] The In Vitro Enhancement of Retinal Cell Viability via m6A and m5C RNA Methylation-Mediated Changes in the Levels of Heme Oxygenase (HO-1) and …

G Betlej, E Bator, A Koziorowska… - International Journal of …, 2024 - mdpi.com
Degenerative retinal diseases can lead to blindness if left untreated. At present, there are no
curative therapies for retinal diseases. Therefore, effective treatment strategies for slowing …

Regulation and application of m6A modification in tumor immunity

Q Xiong, Y Zhang, Y Zheng, Q Zhu - Science China Life Sciences, 2024 - Springer
The m 6 A modification is an RNA modification that impacts various processes of RNA
molecules, including transcription, splicing, stability, and translation. Recently, researchers …

Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians

X Chen - Heliyon, 2025 - cell.com
Regeneration is the ability to accurately regrow missing body parts. The unparalleled
regenerative capacity and incredible tissue plasticity of planarians, both resulting from the …