DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

The proper regulation of apoptosis is essential for the survival of multicellular organisms.
Furthermore, excessive apoptosis can contribute to neurodegenerative diseases, anaemia …

Alkylating agents have been used since the 60ties in brain cancer chemotherapy. Their
target is the DNA and, although the DNA of normal and cancer cells is damaged …

Natural killer (NK) cells are immune cells sensing and eliminating foreign, stressed,
transformed, and senescent cells through specialized surface receptors, such as NKG2D …

Membrane-less organelles (MLOs) are liquid-like subcellular compartments that form
through phase separation of proteins and RNA. While their biophysical properties are …

How cells become malignant has preoccupied scientists for over a century. However, the
converse question is also valid: are tumour cells capable of reverting from their malignant …

Kidney fibrosis is a common process that leads to the progression of various types of kidney
disease. We used an integrated computational and experimental systems biology approach …

The p53 protein is the most studied tumor suppressor and the p53 pathway has been shown
to mediate cellular stress responses that are disrupted when cancer develops. After DNA …

Glycogen synthase kinase 3 beta (GSK3β) is highly inactivated in epithelial cancers and is
known to inhibit tumor migration and invasion. The zinc-finger-containing transcriptional …