Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …

Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated.
Usually, it is the ability of the mitochondria to make ATP appropriately in response to energy …

Mitochondrial Ca2+ homeostasis has a key role in the regulation of aerobic metabolism and
cell survival, but the molecular identity of the Ca2+ channel, the mitochondrial calcium …

Summary Mitochondrial Ca 2+(Ca 2+ m) uptake is mediated by an inner membrane Ca 2+
channel called the uniporter. Ca 2+ uptake is driven by the considerable voltage present …

The endoplasmic reticulum (ER) and mitochondria are tubular organelles with a
characteristic “network structure” that facilitates the formation of interorganellar connections …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

The role of mitochondria in cell metabolism and survival is controlled by calcium signals that
are commonly transmitted at the close associations between mitochondria and endoplasmic …

Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …

Ca 2+ dynamics and oxidative signaling are fundamental mechanisms for mitochondrial
bioenergetics and cell function. The MCU complex is the major pathway by which these …