BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

The TGF-β superfamily is the largest family of secreted proteins in mammals, and members
of the TGF-β family are involved in most developmental and physiological processes …

Lack of an objective, accurate, and noninvasive embryo assessment strategy remains one of
the major challenges encountered in in vitro fertilization. Cumulus and mural granulosa cells …

BACKGROUND The complexity of fertilization failure during assisted reproductive
technologies (ART) is often under-appreciated, as this failure can occur at any number of …

The ovarian follicle luteinizing hormone (LH) signaling molecules that regulate oocyte
meiotic maturation have recently been identified. The LH signal reduces preovulatory follicle …

It is widely recognized that bi-directional communication exists between the human oocyte
and cumulus cells (CCs) which is essential for the production of competent oocytes. CCs …

Single-embryo transfer is becoming increasingly common in in vitro fertilization (IVF)
treatment as a means of reducing multiple pregnancy rates leading to a higher incidence of …

Objective To identify the cumulus cell gene expression associated with oocyte
developmental competence, specifically live birth, after single ET (SET) assisted …