Platelet granules are unique among secretory vesicles in both their content and their life
cycle. Platelets contain three major granule types—dense granules, α-granules, and …

Lysosomes were once considered the end point of endocytosis, simply used for
macromolecule degradation. They are now recognized to be dynamic organelles, able to …

Tetraspanins comprise a large superfamily of cell surface-associated membrane proteins
characterized by four transmembrane domains. They participate in a variety of cellular …

Abstract Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to
endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that …

Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular
compartments with unique composition, morphology and structure that share some features …

Unique functions of specialised cells such as those of the immune and haemostasis
systems, skin, blood vessels, lung, and bone require specialised compartments, collectively …

Summary von W illebrand factor (VWF) plays key roles in both primary and secondary
hemostasis by capturing platelets and chaperoning clotting factor VIII, respectively. It is …

Some cells harbour specialised lysosome-related organelles (LROs) that share features of
late endosomes/lysosomes but are functionally, morphologically and/or compositionally …

Weibel-Palade bodies (WPBs) are secretory organelles used for post-synthesis storage in
endothelial cells that can, very rapidly, be triggered to release their contents. They carry a …

Background: von Willebrand factor (VWF) and fibrinogen are major storage proteins of
platelet α‐granules. VWF is synthesized by the megakaryocyte, the cell from which platelets …