An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities

F Annunziata, C Pinna, S Dallavalle… - International Journal of …, 2020 - mdpi.com
Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …

Osthole: An overview of its sources, biological activities, and modification development

M Sun, M Sun, J Zhang - Medicinal Chemistry Research, 2021 - Springer
Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants
such as Cnidium monnieri and Angelica pubescens. It can be obtained via extraction and …

[HTML][HTML] Vitamin D deficiency and co-morbidities in COVID-19 patients–A fatal relationship?

HK Biesalski - Nfs Journal, 2020 - Elsevier
Infections of the respiratory tract are more frequent in the winter months and especially in the
northern latitudes than they are in summer [1]. This obviously also applies to the COVID-19 …

Simple osthole/nanocarrier pesticide efficiently controls both pests and diseases fulfilling the need of green production of strawberry

S Yan, Q Hu, Q Jiang, H Chen, J Wei… - … Applied Materials & …, 2021 - ACS Publications
The application of botanical pesticides is a good choice in organic agriculture. However,
most botanical pesticides have limitations of slow action and short persistence for pest and …

Possible use of phytochemicals for recovery from COVID-19-induced anosmia and ageusia

S Koyama, K Kondo, R Ueha, H Kashiwadani… - International Journal of …, 2021 - mdpi.com
The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which
escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms …

Ligand-binding sites in vanilloid-subtype TRP channels

MV Yelshanskaya, AI Sobolevsky - Frontiers in Pharmacology, 2022 - frontiersin.org
Vanilloid-subfamily TRP channels TRPV1-6 play important roles in various physiological
processes and are implicated in numerous human diseases. Advances in structural biology …

Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways

B Rostom, R Karaky, I Kassab, MSI Veitía - European Journal of …, 2022 - Elsevier
Natural and synthetic coumarins have been extensively described in the literature as
effective drugs with several pharmacological activities. Many valuable publications have …

Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice

MA Lanaspa, A Andres-Hernando… - The Journal of …, 2018 - Am Soc Clin Investig
Increasing evidence suggests a role for excessive intake of fructose in the Western diet as a
contributor to the current epidemics of metabolic syndrome and obesity. Hereditary fructose …

Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole

A Neuberger, KD Nadezhdin, E Zakharian… - EMBO …, 2021 - embopress.org
TRPV3, a representative of the vanilloid subfamily of TRP channels, is predominantly
expressed in skin keratinocytes and has been implicated in cutaneous sensation and …

Natural and synthetic coumarins with effects on inflammation

G Kirsch, AB Abdelwahab, P Chaimbault - Molecules, 2016 - mdpi.com
In this review, we will present the different aspects of coumarins and derivatives, from natural
origins or synthetically prepared, and their action on inflammation. Coumarins and also furo …