Cancer cells proliferate, differentiate and migrate by repurposing physiological signalling
mechanisms. In particular, altered calcium signalling is emerging as one of the most …

One of the hallmarks of cancer cells is the increased ability to acquire nutrients, particularly
glucose and glutamine. Proliferating cells need precursors for cell growth and NADPH …

Prostate cancer (PCa) is one of the most prevalent malignancies in adult males. However,
PCa is resistant to multi-kinase inhibitors-based anti-angiogenic therapies, and the …

Metabolic adaptation is increasingly recognized as a key factor in tumor progression, yet its
involvement in metastatic bone disease is not understood. Bone is as an adipocyte-rich …

Background: In recent decades, obesity has widely emerged as an important risk factor for
prostate cancer (PCa). Adipose tissue and PCa cells have been shown to orchestrate a …

Simple Summary Obesity is involved in many aspects of prostate cancer progression as a
risk factor for prostate cancer, especially in the process of biochemical recurrence in the …

Persistent androgen receptor (AR) signalling is the main driver of prostate cancer (PCa).
Truncated isoforms of the AR called androgen receptor variants (AR-Vs) lacking the ligand …

Prostate cancer (PCA) is one of the most common cancer types in men, with cancer
progression being linked to hypoxia and the induction of hypoxia-inducible factor (HIF). We …

The clearance of apoptotic cancer cells by macrophages, known as efferocytosis, fuels the
bone-metastatic growth of prostate cancer cells via pro-inflammatory and …

Prostate cancer (PCa) is the second most common cancer in men. The Gleason score (GS)
and biomarkers play important roles in the diagnosis and treatment of patients with PCa. The …