Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral
pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever …

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has caused a huge
number of human deaths. Currently, there are no specific drugs or vaccines available for this …

Highlights•Molecular structures and predicated models of flaviviral NS proteins.•Recent
advance in antiviral development targeting NS proteins.•Inhibitors targeting NS4B entering …

Suppressing cellular signal transducers of transcription 2 (STAT2) is a common strategy that
viruses use to establish infections, yet the detailed mechanism remains elusive, owing to a …

The growing number of zika virus (ZIKV) infections plus a 20-fold increase in neonatal
microcephaly in newborns in Brazil have raised alarms in many countries regarding the …

Zika virus (ZIKV; family Flaviviridae; genus Flavivirus) is a pathogenic mosquito-borne RNA
virus that currently threatens human health in the Americas, large parts of Asia and …

In recent years, the Zika virus has emerged from a neglected flavivirus to a health-
threatening pathogen that causes epidemic outbreaks associated with neurological …

More than 100 chemical modifications of RNA, termed the epitranscriptome, have been
described, most of which occur in prokaryotic and eukaryotic ribosomal, transfer, and …

Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent
reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections …