Perinatal brain injury at term is common and often manifests with neonatal encephalopathy
including seizures. The most common aetiologies are hypoxic–ischaemic encephalopathy …

Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early
hours lack objective measurement tools. Therefore, this systematic review aims to identify …

Objectives To evaluate plasma brain specific proteins and cytokines as biomarkers of brain
injury in newborns with hypoxic-ischemic encephalopathy (HIE) and, secondarily, to assess …

The early detection of perinatal brain damage in preterm and term newborns (ie
intraventricular hemorrhage, periventricular leukomalacia and perinatal asphyxia) still …

Objectives: To determine if candidate biomarkers, ubiquitin carboxyl-terminal esterase L1
and glial fibrillary acidic protein, are elevated in neonates with hypoxic ischemic …

The widespread introduction of therapeutic hypothermia as a standard of care in hypoxic–
ischemic encephalopathy (HIE) has brought increasing pressure on clinicians to make an …

Perinatal asphyxia is caused by lack of oxygen delivery (hypoxia) to end organs due to an
hypoxemic or ischemic insult occurring in temporal proximity to labor (peripartum) or delivery …

Objectives To investigate whether cerebrospinal fluid levels of neuron-specific enolase (CSF-
NSE) during the first 72 hours correlate with other tools used to assess ongoing brain …

A review of the conundrum called mild hypoxic-ischemic encephalopathy (HIE) is provided.
During the past decades, the definition of HIE has evolved to accommodate the short …

Objective Asphyxia can lead to autonomic nervous system dysfunction, including depressed
heart rate variability (HRV). We tested the hypothesis that low HRV is associated with …