Advances in mass spectrometry imaging for spatial cancer metabolomics

X Ma, FM Fernández - Mass spectrometry reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

[HTML][HTML] Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives

N Patil, O Howe, P Cahill, HJ Byrne - Molecular metabolism, 2022 - Elsevier
Background The dynamics of the cellular glycolysis pathway underpin cellular function and
dysfunction, and therefore ultimately health, disease, diagnostic and therapeutic strategies …

A guide to MALDI imaging mass spectrometry for tissues

JL Moore, G Charkoftaki - Journal of Proteome Research, 2023 - ACS Publications
Imaging mass spectrometry is a well-established technology that can easily and succinctly
communicate the spatial localization of molecules within samples. This review …

[HTML][HTML] Plasma metabolome signatures to predict responsiveness to neoadjuvant chemotherapy in breast cancer

AAR Silva, MR Cardoso, DC Oliveira, P Godoy… - Cancers, 2024 - mdpi.com
Simple Summary Neoadjuvant chemotherapy (NACT) is a pivotal treatment for breast cancer
(BC). However, the success of NACT is uncertain and dependent on BC subtype. A valuable …

Mass-spectrometry-based lipidomics discriminates specific changes in lipid classes in healthy and dyslipidemic adults

S Sánchez-Vinces, PHD Garcia, AAR Silva… - Metabolites, 2023 - mdpi.com
Triacylglycerols (TAGs) and cholesterol lipoprotein levels are widely used to predict
cardiovascular risk and metabolic disorders. The aim of this study is to determine how the …

Serum Lipidome Profiling Reveals a Distinct Signature of Ovarian Cancer in Korean Women

S Sah, OO Bifarin, SG Moore, DA Gaul, H Chung… - … Biomarkers & Prevention, 2024 - AACR
Background: Distinguishing ovarian cancer from other gynecological malignancies is crucial
for patient survival yet hindered by non-specific symptoms and limited understanding of …

Fallopian tube secreted protein affects ovarian metabolites in high grade serous ovarian cancer

TM Bergsten, SE Levy, KE Zink, HJ Lusk… - Frontiers in Cell and …, 2022 - frontiersin.org
High grade serous ovarian cancer (HGSOC), the most lethal histotype of ovarian cancer,
frequently arises from fallopian tube epithelial cells (FTE). Once transformed, tumorigenic …

Machine Learning Reveals Lipidome Remodeling Dynamics in a Mouse Model of Ovarian Cancer

OO Bifarin, S Sah, DA Gaul, SG Moore… - Journal of Proteome …, 2023 - ACS Publications
Ovarian cancer (OC) is one of the deadliest cancers affecting the female reproductive
system. It may present little or no symptoms at the early stages and typically unspecific …

DBDA matrix increases ion abundance of fatty acids and sulfatides in MALDI-TOF and mass spectrometry imaging studies

N Khamidova, MR Pergande… - Journal of the …, 2023 - ACS Publications
MALDI-TOF MS is a powerful tool to analyze biomolecules, owing to its soft ionization nature
that generally results in simple spectra of singly charged ions. Implementation of the …

An Early Detection of Ovarian Cancer and The Accurate Spreading Range in Human Body by using Deep Medical Learning Model

V Saravanan, V Sankaradass… - 2023 International …, 2023 - ieeexplore.ieee.org
Current methods of ovarian cancer screening include physical examination, ultrasound, and
blood tests to detect the cancer antagonist (CA-125). All of these are subject to appropriate …