Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …

Chronic pain is an unpleasant and debilitating condition that is often poorly managed by
existing therapeutics. Reciprocal interactions between the nervous system and the immune …

Neuroimmune interactions are essential for the development of neuropathic pain, yet the
contributions of distinct immune cell populations have not been fully unraveled. Here, we …

There is a critical need for effective new pharmacotherapies for pain. The paucity of new
drugs successfully reaching the clinic calls for a reassessment of current analgesic drug …

We tested the hypothesis that epigenetic mechanisms in the brain and the immune system
are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post …

To evaluate changes in DNA methylation profiles in patients with fibromyalgia (FM)
compared to matched healthy controls (HCs). All individuals underwent full clinical and …

Trigeminal (TG) pain often lacks a satisfactory pharmacological control. A better
understanding of the molecular cross‐talk between TG neurons and surrounding satellite …

Background Peripheral nerve injury can have long-term consequences including pain-
related manifestations, such as hypersensitivity to cutaneous stimuli, as well as affective and …

Chronic pain represents a major medical challenge in the 21 st century. Enormous efforts
have been invested towards deciphering the complexity of chronic pain from different angles …

The future of pain medicine is marked by many questions. What can other nations around
the world learn from the opioid crisis that is still affecting the United States? The American …