GatekeepR: an R Shiny application for the identification of nodes with high dynamic impact in Boolean networks

FM Weidner, N Ikonomi, SD Werle, JD Schwab… - …, 2024 - academic.oup.com
Motivation Boolean networks can serve as straightforward models for understanding
processes such as gene regulation, and employing logical rules. These rules can either be …

A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective

SD Werle, N Ikonomi, L Lausser… - npj Systems Biology …, 2023 - nature.com
Pancreatic neuroendocrine tumors (PanNETs) are a rare tumor entity with largely
unpredictable progression and increasing incidence in developed countries. Molecular …

[HTML][HTML] Identification of dynamic driver sets controlling phenotypical landscapes

SD Werle, N Ikonomi, JD Schwab, JM Kraus… - Computational and …, 2022 - Elsevier
Controlling phenotypical landscapes is of vital interest to modern biology. This task becomes
highly demanding because cellular decisions involve complex networks engaging in …

Logical modelling of molecular crosstalks for the prediction of complex phenotypes

N Ikonomi - 2023 - oparu.uni-ulm.de
Abstract Systems biology investigates the understanding of complex biological processes,
such as ageing or cancer, by integrating a holistic view, which is mostly unconsidered when …

Boolean network modeling and its integration with experimental read-outs: An interdisciplinary presentation using a leukemia model

J Maier, JD Schwab, SD Werle, R Marienfeld, P Möller… - Die Pathologie, 2024 - Springer
The limited availability of suitable animal models and cell lines often impedes experimental
cancer research. Wet-laboratory experiments are also time-consuming and cost-intensive. In …

[PDF][PDF] Митохондриальные сети клеток кумулюса и качество ооцитов

ЕВ Панферов, НИ Тапильская, КС Масиева… - 2022 - scholar.archive.org
BACKGROUND: Mitochondria play vital roles in oocyte functions and they are critical
indicators of oocyte quality which is important for fertilization and development into viable …

Mitochondrial networks of cumulus cells and oocyte quality

EV Panferov, NI Tapilskaya… - Russian Military …, 2022 - journals.eco-vector.com
BACKGROUND: Mitochondria play vital roles in oocyte functions and they are critical
indicators of oocyte quality which is important for fertilization and development into viable …

ИЗВЕСТИЯ РОССИЙСКОЙ ВОЕННО-МЕДИЦИНСКОЙ АКАДЕМИИ

ЕВ Панферов, НИ Тапильская, КС Масиева… - ИЗВЕСТИЯ, 2022 - elibrary.ru
Актуальность. Митохондрии играют жизненно важную роль в поддержании
нормального функционирования ооцитов, внутриутробного развития эмбриона и …