TRIM29 promotes DNA virus infections by inhibiting innate immune response
Many double-stranded DNA viruses, such as Epstein-Barr virus, can establish persistent
infection, but the underlying virus–host interactions remain poorly understood. Here we …
infection, but the underlying virus–host interactions remain poorly understood. Here we …
Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5
The interferon (IFN)-mediated antiviral response is a major defense of the host immune
system. In order to complete their life cycle, viruses must modulate host IFN-mediated …
system. In order to complete their life cycle, viruses must modulate host IFN-mediated …
UNC93B1 attenuates the cGAS–STING signaling pathway by targeting STING for autophagy–lysosome degradation
H Zhu, R Zhang, L Yi, YD Tang… - Journal of Medical …, 2022 - Wiley Online Library
Stimulator of interferon genes (STING) is a pivotal innate immune adaptor, and its functions
during DNA virus infections have been extensively documented. However, its homeostatic …
during DNA virus infections have been extensively documented. However, its homeostatic …
Herpes simplex virus 1 ubiquitin-specific protease UL36 abrogates NF-κB activation in DNA sensing signal pathway
R Ye, C Su, H Xu, C Zheng - Journal of virology, 2017 - Am Soc Microbiol
The DNA sensing pathway triggers innate immune responses against DNA virus infection,
and NF-κB signaling plays a critical role in establishing innate immunity. We report here that …
and NF-κB signaling plays a critical role in establishing innate immunity. We report here that …
Herpes simplex virus 1-encoded tegument protein VP16 abrogates the production of beta interferon (IFN) by inhibiting NF-κB activation and blocking IFN regulatory …
Host cells activate innate immune signaling pathways to defend against invading
pathogens. To survive within an infected host, viruses have evolved intricate strategies to …
pathogens. To survive within an infected host, viruses have evolved intricate strategies to …
Herpes simplex virus 1 serine/threonine kinase US3 hyperphosphorylates IRF3 and inhibits beta interferon production
Viral infection initiates a series of signaling cascades that lead to the transcription of
interferons (IFNs), finally inducing interferon-stimulated genes (ISGs) to eliminate viruses …
interferons (IFNs), finally inducing interferon-stimulated genes (ISGs) to eliminate viruses …
Herpes simplex virus 1 ubiquitin-specific protease UL36 inhibits beta interferon production by deubiquitinating TRAF3
Interferon (IFN)-mediated innate immune defense is a potent antiviral mechanism. Viruses
evade innate immunity and limit secretion of beta interferon (IFN-β) to replicate and survive …
evade innate immunity and limit secretion of beta interferon (IFN-β) to replicate and survive …
Herpes simplex virus 1 UL24 abrogates the DNA sensing signal pathway by inhibiting NF-κB activation
ABSTRACT Cyclic GMP-AMP synthase (cGAS) is a newly identified DNA sensor that
recognizes foreign DNA, including the genome of herpes simplex virus 1 (HSV-1). Upon …
recognizes foreign DNA, including the genome of herpes simplex virus 1 (HSV-1). Upon …
[HTML][HTML] DHX15 is required to control RNA virus-induced intestinal inflammation
J Xing, X Zhou, M Fang, E Zhang, LJ Minze, Z Zhang - Cell reports, 2021 - cell.com
RNA helicases play critical roles in various biological processes, including serving as viral
RNA sensors in innate immunity. Here, we find that RNA helicase DEAH-box helicase 15 …
RNA sensors in innate immunity. Here, we find that RNA helicase DEAH-box helicase 15 …
Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3
Varicella-zoster virus (VZV) infection of differentiated cells within the host and establishment
of latency likely requires evasion of innate immunity and limits secretion of antiviral …
of latency likely requires evasion of innate immunity and limits secretion of antiviral …