[HTML][HTML] Aldehyde dehydrogenase 1A1 and 1A3 isoforms–mechanism of activation and regulation in cancer
M Poturnajova, Z Kozovska, M Matuskova - Cellular Signalling, 2021 - Elsevier
In some types of human cancer, aldehyde dehydrogenases represent stemness markers
and their expression is associated with advanced disease stages and poor prognosis …
and their expression is associated with advanced disease stages and poor prognosis …
Targeting aldehyde dehydrogenase enzymes in combination with chemotherapy and immunotherapy: An approach to tackle resistance in cancer cells
SA Al-Shamma, DM Zaher, F Hersi, NNA Jayab… - Life Sciences, 2023 - Elsevier
Modern cancer chemotherapy originated in the 1940s, and since then, many
chemotherapeutic agents have been developed. However, most of these agents show …
chemotherapeutic agents have been developed. However, most of these agents show …
The miR–181a–SFRP4 Axis Regulates Wnt Activation to Drive Stemness and Platinum Resistance in Ovarian Cancer
A Belur Nagaraj, M Knarr, S Sekhar, RS Connor… - Cancer research, 2021 - AACR
Wnt signaling is a major driver of stemness and chemoresistance in ovarian cancer, yet the
genetic drivers that stimulate its expression remain largely unknown. Unlike other cancers …
genetic drivers that stimulate its expression remain largely unknown. Unlike other cancers …
[HTML][HTML] Mechanisms underlying the changes in acetaldehyde dehydrogenase 1 in cholangiocarcinoma
B Ding, Y Song, S Liu, C Peng, Y Zhang - Journal of Cancer, 2023 - ncbi.nlm.nih.gov
Cholangiocarcinoma (CCA) is the most recurrent malignant tumor found in the biliary
system. It originates from the bile duct epithelial cells characterized by easy metastasis, high …
system. It originates from the bile duct epithelial cells characterized by easy metastasis, high …
[HTML][HTML] Cancer stem cell markers: Symphonic masters of chemoresistance and immune evasion
MÁ Sarabia-Sánchez, JM Tinajero-Rodríguez… - Life Sciences, 2024 - Elsevier
Abstract Cancer Stem Cells (CSCs) are highly tumorigenic, chemoresistant, and immune
evasive. They emerge as a central driver that gives rise to the bulk of tumoral mass, modifies …
evasive. They emerge as a central driver that gives rise to the bulk of tumoral mass, modifies …
Inhibition of Selenoprotein I promotes ferroptosis and reverses resistance to platinum chemotherapy by impairing Akt phosphorylation in ovarian cancer
J Li, M Chen, D Huang, Z Li, Y Chen, J Huang… - MedComm, 2024 - Wiley Online Library
Ovarian cancer (OV) ranks among the deadliest gynecological cancer, known for its high risk
of relapse and metastasis, and a general resistance to conventional platinum‐based …
of relapse and metastasis, and a general resistance to conventional platinum‐based …
[HTML][HTML] A novel prognostic signature based on cancer stemness and metabolism-related genes for cervical squamous cell carcinoma and endocervical …
Y Wang, Y Han, L Jin, L Ji, Y Liu, M Lin, S Zhou… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Background: CESC is the second most commonly diagnosed gynecological malignancy.
Given the pivotal involvement of metabolism-related genes (MRGs) in the etiology of …
Given the pivotal involvement of metabolism-related genes (MRGs) in the etiology of …
Hypoxia differently regulates the proportion of ALDHhi cells in lung squamous carcinoma H520 and adenocarcinoma A549 cells via the Wnt/β‐catenin pathway
N Liu, Q Zheng, Y Zhang, H Wang, Z Zhang… - Thoracic …, 2024 - Wiley Online Library
Abstract Background Cancer stem cells (CSCs) are a specific subpopulation of cancer cells
with the ability of self‐renewal, infinite proliferation, multidifferentiation and tumorigenicity …
with the ability of self‐renewal, infinite proliferation, multidifferentiation and tumorigenicity …
Aldehyde Dehydrogenese-1 High Cancer Stem-like Cells/Cancer-initiating Cells Escape from Cytotoxic T Lymphocytes due to Lower Expression of Human Leukocyte …
T Shirosaki, N Kawai, Y Ebihara, A Murai… - Anticancer …, 2024 - ar.iiarjournals.org
Background/Aim: Human gastric cancer stem-like cells (CSCs)/cancer-initiating cells can be
identified as aldehyde dehydrogenase-high (ALDHhigh) cells. Cancer immunotherapy …
identified as aldehyde dehydrogenase-high (ALDHhigh) cells. Cancer immunotherapy …
Elevation of LEM Domain Containing 1 Predicts Poor Prognosis of NSCLC Patients and Triggers Malignant Stemness and Invasion of NSCLC Cells by Stimulating …
L Li, P Zhang - Current Molecular Medicine, 2024 - ingentaconnect.com
Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related
death globally. LEM domain containing 1 (LEMD1) function has been identified in several …
death globally. LEM domain containing 1 (LEMD1) function has been identified in several …