Crosstalk in the pathophysiological processes underpinning metabolic diseases and
neurodegenerative disorders have been the subject of extensive investigation, in which …

Background Lafora disease (LD) is a rare fatal autosomal recessive form of progressive
myoclonus epilepsy. It affects previously healthy children or adolescents, causing …

Liver glycogen α particles are molecularly fragile in diabetic mice, and readily form smaller β
particles, which degrade more rapidly to glucose. This effect is well associated with the loss …

Background Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are
a promising disease model, even though hiPSC-CMs cultured for extended periods display …

Background Lafora progressive myoclonus epilepsy (Lafora disease) is a rare, usually
childhood-onset, fatal neurodegenerative disease caused by biallelic mutations in EPM2A …

Background: Diabetes mellitus (DM), a common metabolic disease, is featured with chronic
hyperglycemia and dysfunction of pancreatic β-cells. Various evidences suggested that …

Background: Obesity is a public health crisis in the US highlighting an urgent need to better
understand obesity's etiology to develop novel therapeutics against obesity. Leptin is a key …